Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (1): 159-162.doi: 10.3969/j.issn.1673-8225.2011. 01.036

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Combined transplantation of neural stem cells and olfactory ensheathing cells for the treatment of cerebral hypoplasia

Tao Xiao-yu1, Liu Bo1, Teng Xiao-hua1, Deng Shi-jie2, Xie Miao-jun3, Xu Rong1, Lu Ming1   

  1. 1Second Affiliated Hospital, Hunan Normal University, Department of Neurosurgery, the 163 Hospital of Chinese PLA, Changsha  410003, Hunan Province, China
    2Second Affiliated Hospital, Hunan Normal University, Medical Image Center, the 163 Hospital of Chinese PLA, Changsha  410003, Hunan Province, China
    3Department of Teaching and Research, Chinese People's Armed Police Force Academy in Chengdu, Chengdu 610213, Sichuan Province, China
  • Received:2010-08-04 Revised:2010-10-18 Online:2011-01-01 Published:2011-01-01
  • Contact: Lu Ming, Doctor, Chief physician, Second Affiliated Hospital, Hunan Normal University, Department of Neurosurgery, the 163 Hospital of Chinese PLA, Changsha 410003, Hunan Province, China
  • About author:Tao Xiao-yu★, Studying for master’s degree, Second Affiliated Hospital, Hunan Normal University, Department of Neurosurgery, the 163 Hospital of Chinese PLA, Changsha 410003, Hunan Province, China lichenyu0913@yahoo.com.cn
  • Supported by:

    the Grant of Department of Science and Technology of Hunan Province, No. 2008FJ3061; the Key Science and Technology Program of the Chinese PLA during the 11th “Five-Year” Plan Period, No. 06G044

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Abstract:

BACKGROUND: Recent years, stem cell replacement therapy furnishes a new method for neural regeneration. But until now, we have not found the reports about stem cell transplantation for treating cerebral hypoplasia.
OBJECTIVE: To explore the effectiveness of combined transplantation of neural stem cells and olfactory ensheathing cells for the repair of cerebral hypoplasia.
METHODS: In October, 2009, a cerebral hypoplasia patient was enrolled at the 163 Hospital of the Chinese People’s Liberation Army. We used the treatment of physical cooling, neurotrophic, maintenance of water-electrolyte balance, hyperbaric oxygen. We selected the point of puncture between the L3-4 of the spine and injected neural stem cells (about 8×107) and olfactory ensheathing cells (about 4×107) slowly into the subarachnoid space, once two weeks, twice as a course, totally one course. We assessed the results of transplantation treatment by drop of body temperature, fine motor, motor coordination and language expression.
RESULTS AND CONCLUSION: The body temperature decreased to normal level, and muscular tension reduced obviously after one month, he could sit up by himself after two months, walk under the help of handrail, and have simple language expression after three months. These indicated that it is effective to treat cerebral hypoplasia and can recover central nerve function by combined transplantation of neural stem cells and olfactory ensheathing cells.

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